發佈日期：2018-02-22 ∣ 徵才
Postdoctoral positions available in the Center for Complex Biological Systems, University of California, Irvine, California, USA
Two fully-funded positions are available for postdoctoral scholars interested in using mouse molecular genetics, genomics, and computational models to understand fundamental problems in nervous system and heart development and morphogenesis.
One project focuses on the polygenic basis of congenital heart defects and the transcriptional identity of heart progenitor cells in mouse models of mammalian heart development. Research for the heart project will be focused on understanding how multiple small perturbations to gene expression act collectively to produce heart defects in multi-system birth defects disorders known as transcriptomopathies.
The second project exploits mathematical modeling and genetically-engineered mice to discover how the sizes of neural tissues are precisely specified in the face of developmental variability and external perturbations. Experimental work will focus on transient stem/progenitor cell ablations and their effects on development of neural structures. Experimental data will be used to validate models of strategies for tissue size control. This work is of direct relevance to the etiology of microcephaly and other neural birth defects.
Successful applicants will have a Ph.D. in molecular and/or developmental biology, neurobiology, genetics, or genomics, and evidence of publication and/or preparation of high quality journal article(s). Successful applicants will have training that provides sufficient preparation for them to be able to use mouse genetics, embryology, molecular biology, high resolution optical imaging (including optical projection tomography and magnetic resolution imaging), together with genomics (RNA sequencing/bioinformatics) to identify morphogenetic abnormalities (progenitor cell proliferation, patterning and migration) and gene expression changes. Single-cell RNA sequencing of early mouse embryos will be used to identify relevant transcriptional changes in individual progenitor cells.
The salary ranges for these positions are negotiable and will be commensurate with training and experience; healthcare benefits are included. Appointments will initially be for a one-year period with extensions for up to 4 years, subject to performance.
Please send inquiries to:
Anne L. Calof, Professor, CCBS (firstname.lastname@example.org)
Arthur D. Lander, Professor and Director, CCBS (email@example.com)